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Description
FITC Rat Anti-Mouse CD4 Antibody (S-R382)Product Specification Host Rat Antigen CD4 Synonyms T cell surface glycoprotein CD4; T cell differentiation antigen L3T4; T cell surface antigen T4 Leu 3 Location Cell membrane Accession P06332 Clone Number S R382 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 05mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1%
Product Specification
| Host | Rat |
| Antigen | CD4 |
| Synonyms | T-cell surface glycoprotein CD4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3 |
| Location | Cell membrane |
| Accession | P06332 |
| Clone Number | S-R382 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD4, also known as cluster of differentiation 4, is a glycoprotein found on the surface of certain immune cells, particularly T helper cells. It plays a crucial role in the immune system by acting as a co-receptor for the T cell receptor (TCR) in recognizing antigens presented by major histocompatibility complex class II (MHC II) molecules. This interaction is essential for the activation of T helper cells, which then release cytokines to coordinate the immune response, including activating B cells to produce antibodies and stimulating cytotoxic T cells to destroy infected cells. CD4 is also the primary receptor targeted by HIV, leading to a significant depletion of CD4+ T cells in infected individuals, which compromises their immune system. In addition to T cells, CD4 is expressed on the surface of monocytes, macrophages, and dendritic cells, where it plays roles in cell differentiation and cytokine expression.
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