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Description
APC Rat Anti-Mouse CD8α Antibody (S-R540)Product Specification Host Rat Antigen CD8 Synonyms T cell surface glycoprotein CD8 alpha chain; T cell surface glycoprotein Lyt 2; Lyt 2; Lyt2 Location Cell membrane Accession P01731 Clone Number S R540 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Rat |
| Antigen | CD8α |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; Lyt-2; Lyt2 |
| Location | Cell membrane |
| Accession | P01731 |
| Clone Number | S-R540 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD8α is a crucial immune glycoprotein that serves as a co-receptor for MHC class I peptide complexes, facilitating the connection between T cells and antigens presented by antigen-presenting cells (APCs). It interacts with the T-cell receptor (TCR) and MHC class I molecules, recruits LCK kinase, and initiates multiple signaling pathways. CD8α can exist as either an α/β heterodimer or an α/α homodimer, with the αα homodimer being particularly abundant in intraepithelial lymphocytes (IELs) that protect mucosal surfaces. It is expressed on cytotoxic T cells (CTLs) and natural killer (NK) cells, playing a key role in cell-mediated immunity and the regulation of immune responses. Additionally, CD8α is involved in T cell activation and differentiation, and it is a biomarker for various diseases, including COVID-19 and certain cancers.
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Exchange/Return Notes
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